Calcium (Calcium Carbonate)
Calcium, the most abundant mineral in the body, less than 1% of total body calcium is needed to support these critical metabolic functions, the remaining 99% of the body’s calcium supply is stored in the bones and teeth where it supports their structure and function.

A naturally occurring element, calcium carbonate exists in oyster shells, limestone and chalk, and become calcium supplements. Elemental calcium is the amount of calcium actually absorbed by the body, for example, there is more elemental calcium in calcium carbonate compared with other form of Calcium. Calcium carbonate contains 40% of elemental calcium making it the highest concentration of calcium in supplement form for maximum absorption.

Bone itself undergoes continuous remodeling, with constant resorption and deposition of calcium into new bone. The balance between bone resorption and deposition changes with age. Bone formation exceeds resorption in periods of growth in children and adolescents, whereas in early and middle adulthood both processes are relatively equal.

Bones increase in size and mass during periods of growth in childhood and adolescence, reaching peak bone mass around age 30. The greater the peak bone mass, the longer one can delay serious bone loss with increasing age. Everyone should therefore consume adequate amounts of calcium and vitamin D throughout childhood, adolescence, and early adulthood.

In aging adults, bone loss also occurs as part of the normal aging process, particularly in postmenopausal women due to decreased amounts of estrogen, bone breakdown exceeds formation, resulting in bone loss that increases the risk of osteoporosis over time.

Many factors increase the risk of developing osteoporosis, including being female, thin, inactive, or of advanced age; smoking cigarettes; drinking excessive amounts of alcohol; and having a family history of osteoporosis.

Osteoporosis, a disorder characterized by porous and fragile bones, is a serious public health problem for more than 10 million U.S. adults, 80% of whom are women.

The two main forms of calcium in supplements are carbonate and citrate. Calcium carbonate is more commonly available and is both inexpensive and convenient. Due to its dependence on stomach acid for absorption, calcium carbonate is absorbed most efficiently when taken with food, whereas calcium citrate is absorbed equally well when taken with or without food. Calcium carbonate is 40% calcium by weight, whereas calcium citrate is 21% calcium.

Magnesium
Magnesium is one of the essential macro mineral, involved in bone formation and influences the activities of osteoblasts and osteoclasts. Magnesium also affects the concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis. Several population-based studies have found positive associations between magnesium intake and bone mineral density in both men and women. Other research has found that women with osteoporosis have lower serum magnesium.

Nearly every tissue and cell in our body has a vitamin D receptor. Without enough activated vitamin D in the body, dietary calcium cannot be absorbed. Magnesium play a role of active transporter of calcium and potassium ions across cell membranes, it helps to regulate calcium transport and aid in  the influx of calcium into bones.

Magnesium also works with ATP to release the energy needed for many reactions in the body. It plays an important role in protein formation, nerve impulse conduction, a healthy muscle function and contraction, and a normal heart rhythm.

Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation.

Magnesium is required for energy production, oxidative phosphorylation, and glycolysis. It contributes to the structural development of bone and is required for the synthesis of DNA, RNA, and the antioxidant glutathione.

The American Academy of Neurology and the American Headache Society concluded that magnesium therapy is “probably effective” for migraine prevention.

Magnesium is also a primary ingredient in some laxatives, and is included in some remedies for heartburn and upset stomach due to acid indigestion.

Vitamin D3
Vitamin D, obtained from food and produced by skin when exposed to sunlight of sufficient intensity, improves calcium absorption. Supplementation with calcium plus vitamin D has been shown to be effective in reducing fractures and falls (which can cause fractures) in institutionalized older adults.

Calcium is essential for signaling between brain cells, development of bone, and tooth formation. Let’s be honest, nobody likes rickets.

Studies also reveal that low vitamin D levels in the body are associated with:

• Increased loss of muscle strength and mass as we age
• Increased risk of cancers
• Lower levels of immunity
• Higher blood pressure
• The development of neurological disorders
• The development of diabetes

In 1993, the FDA authorized a health claim related to calcium and osteoporosis for foods and supplements. In January 2010, this health claim was expanded to include vitamin D. Model health claims include the following: “Adequate calcium throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis” and “Adequate calcium and vitamin D as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis in later life” .

Zinc
Zinc, a trace mineral that plays a role in the synthesis of collagen in bone tissue. Is also participates in antioxidant processes and involved in numerous aspects of cellular metabolism. It is required for the catalytic activity of approximately 100 enzymes and it plays a role in immune function, protein synthesis, wound healing, DNA synthesis and cell division.

Each softgel (1998.2 mg) contains:

• Elemental calcium (300 mg)
• Elemental magnesium (120 mg)
• Elemental zinc (8 mg)
• Vitamin D3 (200 IU)

Used as health supplement

Adults: Take 1 softgel once daily after meal

Keep out of reach of children

• Store below 30°C
• Best to consume within 2 months from open cap